Toxic inhalational injury-associated interstitial lung disease in children.
Identifieur interne : 001104 ( Main/Exploration ); précédent : 001103; suivant : 001105Toxic inhalational injury-associated interstitial lung disease in children.
Auteurs : Eun Lee [Corée du Sud] ; Ju-Hee Seo ; Hyung Young Kim ; Jinho Yu ; Won-Kyoung Jhang ; Seong-Jong Park ; Ji-Won Kwon ; Byoung-Ju Kim ; Kyung-Hyun Do ; Young Ah Cho ; Sun-A Kim ; Se Jin Jang ; Soo-Jong HongSource :
- Journal of Korean medical science [ 1598-6357 ] ; 2013.
Descripteurs français
- KwdFr :
- Antienzymes (usage thérapeutique), Bronches (anatomopathologie), Cyclophosphamide (usage thérapeutique), Dyspnée (étiologie), Désinfectants (toxicité), Enfant d'âge préscolaire, Humains, Hydroxychloroquine (usage thérapeutique), Immunoglobulines (usage thérapeutique), Indice Apache, Inspiration, Nourrisson, Pneumopathies interstitielles (), Pneumopathies interstitielles (anatomopathologie), Pneumopathies interstitielles (traitement médicamenteux), Pronostic, Stéroïdes (usage thérapeutique), Tomodensitométrie, Toux (étiologie), Études rétrospectives.
- MESH :
- anatomopathologie : Bronches, Pneumopathies interstitielles.
- toxicité : Désinfectants.
- traitement médicamenteux : Pneumopathies interstitielles.
- usage thérapeutique : Antienzymes, Cyclophosphamide, Hydroxychloroquine, Immunoglobulines, Stéroïdes.
- étiologie : Dyspnée, Toux.
- Enfant d'âge préscolaire, Humains, Indice Apache, Inspiration, Nourrisson, Pneumopathies interstitielles, Pronostic, Tomodensitométrie, Études rétrospectives.
English descriptors
- KwdEn :
- APACHE, Bronchi (pathology), Child, Preschool, Cough (etiology), Cyclophosphamide (therapeutic use), Disinfectants (toxicity), Dyspnea (etiology), Enzyme Inhibitors (therapeutic use), Humans, Hydroxychloroquine (therapeutic use), Immunoglobulins (therapeutic use), Infant, Inhalation, Lung Diseases, Interstitial (chemically induced), Lung Diseases, Interstitial (drug therapy), Lung Diseases, Interstitial (pathology), Prognosis, Retrospective Studies, Steroids (therapeutic use), Tomography, X-Ray Computed.
- MESH :
- chemical , therapeutic use : Cyclophosphamide, Enzyme Inhibitors, Hydroxychloroquine, Immunoglobulins, Steroids.
- chemically induced : Lung Diseases, Interstitial.
- drug therapy : Lung Diseases, Interstitial.
- etiology : Cough, Dyspnea.
- pathology : Bronchi, Lung Diseases, Interstitial.
- chemical , toxicity : Disinfectants.
- APACHE, Child, Preschool, Humans, Infant, Inhalation, Prognosis, Retrospective Studies, Tomography, X-Ray Computed.
Abstract
Interstitial lung disease in children (chILD) is a group of disorders characterized by lung inflammation and interstitial fibrosis. In the past recent years, we noted an outbreak of child in Korea, which is possibly associated with inhalation toxicity. Here, we report a series of cases involving toxic inhalational injury-associated chILD with bronchiolitis obliterans pattern in Korean children. This study included 16 pediatric patients confirmed by lung biopsy and chest computed tomography, between February 2006 and May 2011 at Asan Medical Center Children's Hospital. The most common presenting symptoms were cough and dyspnea. The median age at presentation was 26 months (range: 12-47 months), with high mortality (44%). Histopathological analysis showed bronchiolar destruction and centrilobular distribution of alveolar destruction by inflammatory and fibroproliferative process with subpleural sparing. Chest computed tomography showed ground-glass opacities and consolidation in the early phase and diffuse centrilobular nodular opacity in the late phase. Air leak with severe respiratory difficulty was associated with poor prognosis. Although respiratory chemicals such as humidifier disinfectants were strongly considered as a cause of this disease, further studies are needed to understand the etiology and pathophysiology of the disease to improve the prognosis and allow early diagnosis and treatment.
DOI: 10.3346/jkms.2013.28.6.915
PubMed: 23772158
Affiliations:
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Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Ju Hee" sort="Seo, Ju Hee" uniqKey="Seo J" first="Ju-Hee" last="Seo">Ju-Hee Seo</name></author><author><name sortKey="Kim, Hyung Young" sort="Kim, Hyung Young" uniqKey="Kim H" first="Hyung Young" last="Kim">Hyung Young Kim</name></author><author><name sortKey="Yu, Jinho" sort="Yu, Jinho" uniqKey="Yu J" first="Jinho" last="Yu">Jinho Yu</name></author><author><name sortKey="Jhang, Won Kyoung" sort="Jhang, Won Kyoung" uniqKey="Jhang W" first="Won-Kyoung" last="Jhang">Won-Kyoung Jhang</name></author><author><name sortKey="Park, Seong Jong" sort="Park, Seong Jong" uniqKey="Park S" first="Seong-Jong" last="Park">Seong-Jong Park</name></author><author><name sortKey="Kwon, Ji Won" sort="Kwon, Ji Won" uniqKey="Kwon J" first="Ji-Won" last="Kwon">Ji-Won Kwon</name></author><author><name sortKey="Kim, Byoung Ju" sort="Kim, Byoung Ju" uniqKey="Kim B" first="Byoung-Ju" last="Kim">Byoung-Ju Kim</name></author><author><name sortKey="Do, Kyung Hyun" sort="Do, Kyung Hyun" uniqKey="Do K" first="Kyung-Hyun" last="Do">Kyung-Hyun Do</name></author><author><name sortKey="Cho, Young Ah" sort="Cho, Young Ah" uniqKey="Cho Y" first="Young Ah" last="Cho">Young Ah Cho</name></author><author><name sortKey="Kim, Sun A" sort="Kim, Sun A" uniqKey="Kim S" first="Sun-A" last="Kim">Sun-A Kim</name></author><author><name sortKey="Jang, Se Jin" sort="Jang, Se Jin" uniqKey="Jang S" first="Se Jin" last="Jang">Se Jin Jang</name></author><author><name sortKey="Hong, Soo Jong" sort="Hong, Soo Jong" uniqKey="Hong S" first="Soo-Jong" last="Hong">Soo-Jong Hong</name></author></analytic><series><title level="j">Journal of Korean medical science</title><idno type="eISSN">1598-6357</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APACHE</term><term>Bronchi (pathology)</term><term>Child, Preschool</term><term>Cough (etiology)</term><term>Cyclophosphamide (therapeutic use)</term><term>Disinfectants (toxicity)</term><term>Dyspnea (etiology)</term><term>Enzyme Inhibitors (therapeutic use)</term><term>Humans</term><term>Hydroxychloroquine (therapeutic use)</term><term>Immunoglobulins (therapeutic use)</term><term>Infant</term><term>Inhalation</term><term>Lung Diseases, Interstitial (chemically induced)</term><term>Lung Diseases, Interstitial (drug therapy)</term><term>Lung Diseases, Interstitial (pathology)</term><term>Prognosis</term><term>Retrospective Studies</term><term>Steroids (therapeutic use)</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antienzymes (usage thérapeutique)</term><term>Bronches (anatomopathologie)</term><term>Cyclophosphamide (usage thérapeutique)</term><term>Dyspnée (étiologie)</term><term>Désinfectants (toxicité)</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Immunoglobulines (usage thérapeutique)</term><term>Indice Apache</term><term>Inspiration</term><term>Nourrisson</term><term>Pneumopathies interstitielles ()</term><term>Pneumopathies interstitielles (anatomopathologie)</term><term>Pneumopathies interstitielles (traitement médicamenteux)</term><term>Pronostic</term><term>Stéroïdes (usage thérapeutique)</term><term>Tomodensitométrie</term><term>Toux (étiologie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cyclophosphamide</term><term>Enzyme Inhibitors</term><term>Hydroxychloroquine</term><term>Immunoglobulins</term><term>Steroids</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bronches</term><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cough</term><term>Dyspnea</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bronchi</term><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Disinfectants</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Désinfectants</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antienzymes</term><term>Cyclophosphamide</term><term>Hydroxychloroquine</term><term>Immunoglobulines</term><term>Stéroïdes</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dyspnée</term><term>Toux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>APACHE</term><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Inhalation</term><term>Prognosis</term><term>Retrospective Studies</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Indice Apache</term><term>Inspiration</term><term>Nourrisson</term><term>Pneumopathies interstitielles</term><term>Pronostic</term><term>Tomodensitométrie</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Interstitial lung disease in children (chILD) is a group of disorders characterized by lung inflammation and interstitial fibrosis. In the past recent years, we noted an outbreak of child in Korea, which is possibly associated with inhalation toxicity. Here, we report a series of cases involving toxic inhalational injury-associated chILD with bronchiolitis obliterans pattern in Korean children. This study included 16 pediatric patients confirmed by lung biopsy and chest computed tomography, between February 2006 and May 2011 at Asan Medical Center Children's Hospital. The most common presenting symptoms were cough and dyspnea. The median age at presentation was 26 months (range: 12-47 months), with high mortality (44%). Histopathological analysis showed bronchiolar destruction and centrilobular distribution of alveolar destruction by inflammatory and fibroproliferative process with subpleural sparing. Chest computed tomography showed ground-glass opacities and consolidation in the early phase and diffuse centrilobular nodular opacity in the late phase. Air leak with severe respiratory difficulty was associated with poor prognosis. Although respiratory chemicals such as humidifier disinfectants were strongly considered as a cause of this disease, further studies are needed to understand the etiology and pathophysiology of the disease to improve the prognosis and allow early diagnosis and treatment.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Cho, Young Ah" sort="Cho, Young Ah" uniqKey="Cho Y" first="Young Ah" last="Cho">Young Ah Cho</name><name sortKey="Do, Kyung Hyun" sort="Do, Kyung Hyun" uniqKey="Do K" first="Kyung-Hyun" last="Do">Kyung-Hyun Do</name><name sortKey="Hong, Soo Jong" sort="Hong, Soo Jong" uniqKey="Hong S" first="Soo-Jong" last="Hong">Soo-Jong Hong</name><name sortKey="Jang, Se Jin" sort="Jang, Se Jin" uniqKey="Jang S" first="Se Jin" last="Jang">Se Jin Jang</name><name sortKey="Jhang, Won Kyoung" sort="Jhang, Won Kyoung" uniqKey="Jhang W" first="Won-Kyoung" last="Jhang">Won-Kyoung Jhang</name><name sortKey="Kim, Byoung Ju" sort="Kim, Byoung Ju" uniqKey="Kim B" first="Byoung-Ju" last="Kim">Byoung-Ju Kim</name><name sortKey="Kim, Hyung Young" sort="Kim, Hyung Young" uniqKey="Kim H" first="Hyung Young" last="Kim">Hyung Young Kim</name><name sortKey="Kim, Sun A" sort="Kim, Sun A" uniqKey="Kim S" first="Sun-A" last="Kim">Sun-A Kim</name><name sortKey="Kwon, Ji Won" sort="Kwon, Ji Won" uniqKey="Kwon J" first="Ji-Won" last="Kwon">Ji-Won Kwon</name><name sortKey="Park, Seong Jong" sort="Park, Seong Jong" uniqKey="Park S" first="Seong-Jong" last="Park">Seong-Jong Park</name><name sortKey="Seo, Ju Hee" sort="Seo, Ju Hee" uniqKey="Seo J" first="Ju-Hee" last="Seo">Ju-Hee Seo</name><name sortKey="Yu, Jinho" sort="Yu, Jinho" uniqKey="Yu J" first="Jinho" last="Yu">Jinho Yu</name></noCountry><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Eun" sort="Lee, Eun" uniqKey="Lee E" first="Eun" last="Lee">Eun Lee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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